The Global Isaac Mertens Syndrome Market Size is Expected to Grow from USD 345.28 Million in 2024 to USD 573.31 Million by 2035, at a CAGR 4.72% during the forecast period 2025 To 2035.Diagnosis of Isaac Mertens Syndrome involves clinical evaluation of muscle stiffness, cramps, and twitching symptoms. Electromyography (EMG) is used to detect abnormal nerve activity.